[The role of blood alcohol dehydrogenase in pathological alcohol involvement]

Abstract

The authors have revealed the distinct parallelism between clinical state of patients with alcoholism, activity of alcohol dehydrogenase (ADG) in their blood plasma and presence of signs of pathologic inclination for alcohol (PIA). The marked PIA signs were accompanied by high ADG activity in blood. It permits to combine the presence of PIA and enzyme high activity into single pathogenetic mechanism and suggest that together with metabolic function ADG performs the receptor one. Also it is possible to assume that use of drugs decreasing ADG activity and restoring ethanol content in organism of patients with alcoholism will contribute to PIA release. Use of such drugs can become one of the safe methods in alcoholism therapy.