Microcalorimetric study of the toxic effect of sodium selenite on the mitochondria metabolism of Carassius auratus liver

Abstract

The fundamental thermogenesis curves of the metabolic process of liver mitochondria from Carassius auratus and the toxic effect of Na2SeO3 on it were studied by using an LKB-2277 bioactivity monitor, ampoule method, at 28 degrees C. From the thermogenesis curves, the thermokinetic equations were established under different conditions. The kinetics show that a low concentration of Na2SeO3 (1-4 mg/L) had promoting action on the metabolism process of Carassius aurantus liver mitochondria, but that a high concentration of Na2SeO3 (8-16 mg/L) inhibited the mitochondria metabolism.