Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2001 Jan;13(1):25-9.
doi: 10.1097/00042737-200101000-00005.

Favourable effect of an acidified milk (LC-1) on Helicobacter pylori gastritis in man

C P Felley  1 , I Corthésy-Theulaz, J L Rivero, P Sipponen, M Kaufmann, P Bauerfeind, P H Wiesel, D Brassart, A Pfeifer, A L Blum, P Michetti
Affiliations
Clinical Trial

Favourable effect of an acidified milk (LC-1) on Helicobacter pylori gastritis in man

C P Felley et al. Eur J Gastroenterol Hepatol. 2001 Jan.

Abstract

Objective: The supernatant of Lactobacillus johnsonii La1 culture was shown to be bactericidal and to have a partial, acid-independent suppressive effect on Helicobacter pylori in humans. The aim of the present study was to investigate the effect of L. johnsonii La1-acidified milk (LC-1) on H. pylori infection.

Design and methods: Fifty-three volunteers infected with H. pylori as determined by positive 13C-urea breath test and positive serology were randomized to receive either LC-1 or a placebo 180 ml twice a day for 3 weeks. All subjects also received clarithromycin 500 mg bid during the last two weeks of acidified milk therapy. Oesophagogastroduodenoscopy and biopsies were performed at inclusion and repeated 4-8 weeks after the end of the treatment. H. pylori infection was confirmed by urease test and histology. H. pylori density and inflammation were scored using a modified Sydney classification.

Results: LC-1 ingestion induced a decrease in H. pylori density in the antrum (P= 0.02) and the corpus (P= 0.04). LC-1 also reduced inflammation and gastritis activity in the antrum (P= 0.02 and P= 0.01, respectively) and of activity in the corpus (P= 0.02). Clarithromycin eradicated H. pylori in 26% of the subjects; LC-1 did not improve the antibiotic effect.

Conclusion: These results suggest that H. pylori infection and gastritis can be down-regulated by LC-1.

PubMed Disclaimer

Publication types