Review
doi: 10.1007/978-3-7091-6301-6_18.
GDF-15/MIC-1 a novel member of the TGF-beta superfamily
Affiliations
- PMID: 11205146
- DOI: 10.1007/978-3-7091-6301-6_18
Item in Clipboard
Review
GDF-15/MIC-1 a novel member of the TGF-beta superfamily
J Neural Transm Suppl.
2000.
Abstract
We have cloned, expressed, and raised antibodies against a novel member of the TGF-beta superfamily, growth/differentiation factor-15 (GDF-15). The predicted protein is identical to macrophage inhibitory cytokine-1 (MIC-1), which was discovered simultaneously. GDF-15 is a more distant member of the TGF-beta superfamily and does not belong to one of the known TGF-beta subfamilies. In the CNS, GDF-15/MIC-1 mRNA is abundantly expressed by the choroid plexus. In addition we have preliminary evidence that GDF-15/MIC-1 is a potent trophic factor for selected classes of neurons in vitro and in vivo. Thus, GDF-15 is a novel neurotrophic factor with prospects for the treatment of disorders of the CNS.
Similar articles
-
Expression of growth differentiation factor-15/ macrophage inhibitory cytokine-1 (GDF-15/MIC-1) in the perinatal, adult, and injured rat brain.J Comp Neurol. 2001 Oct 8;439(1):32-45. doi: 10.1002/cne.1333. J Comp Neurol. 2001. PMID: 11579380
-
Growth/differentiation factor-15/macrophage inhibitory cytokine-1 is a novel trophic factor for midbrain dopaminergic neurons in vivo.J Neurosci. 2000 Dec 1;20(23):8597-603. doi: 10.1523/JNEUROSCI.20-23-08597.2000. J Neurosci. 2000. PMID: 11102463 Free PMC article.
-
Expression of a novel member of the TGF-beta superfamily, growth/differentiation factor-15/macrophage-inhibiting cytokine-1 (GDF-15/MIC-1) in adult rat tissues.Cell Tissue Res. 1999 Jul;297(1):103-10. doi: 10.1007/s004410051337. Cell Tissue Res. 1999. PMID: 10398887
-
Growth/differentiation factor-15 (GDF-15), a novel member of the TGF-beta superfamily, promotes survival of lesioned mesencephalic dopaminergic neurons in vitro and in vivo and is induced in neurons following cortical lesioning.J Neural Transm Suppl. 2003;(65):197-203. doi: 10.1007/978-3-7091-0643-3_12. J Neural Transm Suppl. 2003. PMID: 12946057 Review.
-
TGF-beta and the regulation of neuron survival and death.J Physiol Paris. 2002 Jan-Mar;96(1-2):25-30. doi: 10.1016/s0928-4257(01)00077-8. J Physiol Paris. 2002. PMID: 11755780 Review.
Cited by
-
The Upregulation of Caffeic Acid Phenethyl Ester on Growth Differentiation Factor 15 Inhibits Transforming Growth Factor β/Smad Signaling in Bladder Carcinoma Cells.Biomedicines. 2022 Jul 7;10(7):1625. doi: 10.3390/biomedicines10071625. Biomedicines. 2022. PMID: 35884930 Free PMC article.
-
GDF15 Mediates the Effect of Skeletal Muscle Contraction on Glucose-Stimulated Insulin Secretion.Diabetes. 2023 Aug 1;72(8):1070-1082. doi: 10.2337/db22-0019. Diabetes. 2023. PMID: 37224335 Free PMC article.
-
Plasma cytokines can help to identify the development of severe acute pancreatitis on admission.Medicine (Baltimore). 2017 Jul;96(28):e7312. doi: 10.1097/MD.0000000000007312. Medicine (Baltimore). 2017. PMID: 28700471 Free PMC article.
-
Plasma growth differentiation factor-15 independently predicts all-cause and cardiovascular mortality as well as deterioration of kidney function in type 1 diabetic patients with nephropathy.Diabetes Care. 2010 Jul;33(7):1567-72. doi: 10.2337/dc09-2174. Epub 2010 Mar 31. Diabetes Care. 2010. PMID: 20357380 Free PMC article.
-
Central mechanisms of emesis: A role for GDF15.Neurogastroenterol Motil. 2025 Mar;37(3):e14886. doi: 10.1111/nmo.14886. Epub 2024 Aug 6. Neurogastroenterol Motil. 2025. PMID: 39108013 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources