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. 2001 Jan 22;11(2):183-5.
doi: 10.1016/s0960-894x(00)00635-1.

3,28-Di-O-(dimethylsuccinyl)-betulin isomers as anti-HIV agents

Y Kashiwada  1 , J Chiyo, Y Ikeshiro, T Nagao, H Okabe, L M Cosentino, K Fowke, K H Lee
Affiliations

3,28-Di-O-(dimethylsuccinyl)-betulin isomers as anti-HIV agents

Y Kashiwada et al. Bioorg Med Chem Lett. .

Abstract

Four isomers of 3,28-di-O-(dimethylsuccinyl)-betulin were prepared and evaluated for anti-HIV activity against HIV-1 replication in H9 lymphocyte cells. 3-O-(3',3'-Dimethylsuccinyl)-28-O-(2", 2"-dimethvlsuccinyl)-betulin (11) was the most potent anti-HIV compound with an EC5, value of 0.00087 microM and a TI value of 42,400.

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