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Comment
. 2001 Jan 16;98(2):398-400.
doi: 10.1073/pnas.98.2.398.

Can mosaic tumor vessels facilitate molecular diagnosis of cancer?

J Folkman  1
Affiliations
Comment

Can mosaic tumor vessels facilitate molecular diagnosis of cancer?

J Folkman. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Figure 1
Figure 1
Cross-sections of breast cancer (MCa-IV) in mice showing the microcylinders of tumor cells that surround each vessel. Large and small thin-walled microvessels in breast tumor labeled by vascular perfusion of green (FITC) fluorescent lectin staining (A), or by CD31 immunoreactivity viewed by Cy3 fluorescence (gold) (C). The perivascular cuff of tumor tissue, outlined by white dots in A and C, is 100 microns thick, which is within the range of the oxygen diffusion limit. In B, two endothelial cells (red cytoplasm with white nuclei) have been drawn facing the lumen to approximate scale. Yellow tumor cells with brown-red nuclei occupy the perivascular cuff of tumor tissue. One tumor cell is intravasating into the lumen and is exposed to the blood between the two endothelial cells. This tumor cell represents the approximately one million tumor cells per gram of tumor that may shed into the circulation each day. The CD31 immunoreactivity, like the lectin in A and B, defines the luminal surface of the vessels, but, unlike the lectin, it also labels tiny sprouts (white arrows), which have no apparent lumen because they have CD31 immunoreactivity, but no lectin staining. These sprouts of about 1 μm diameter radiate from the vessel lining into the 100 μm thick perivascular cuff of tumor tissue. The sprouts result from endothelial cells that are migrating (extravasating) from the wall of the microvessel. Vessels were preserved in the open state by vascular perfusion of fixative (courtesy of Donald M. McDonald, University of California, San Francisco) (2, 23). (Drawings in B by J.F. and Kristin Gullage.) [Reproduced with permission from ref. (Copyright 2000, B. C. Decker).]
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References

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