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. 1975 Feb;18(2):142-8.
doi: 10.1021/jm00236a006.

Antiarrhythmic agents. 2-, 3-, And 4-substituted benzylamines

D C Remy, W A Van Saun Jr, E L Engelhardt

Antiarrhythmic agents. 2-, 3-, And 4-substituted benzylamines

D C Remy et al. J Med Chem. 1975 Feb.

Abstract

The synthesis of a series of 2-, 3-, and 4-substituted benzylamine derivatives is described. These compounds were studied for their effect on experimental cardiac arrhythmias. Many of the derivatives, but in particular 2-(p-methoxyphenylethynyl)benzylamine (3d), alpha,alpha-dimethyl-4y(phenylethynyl)benzylamine (7a), and alpha,alpha-dimethyl-4-phenethylbenzylamine (12g), showed good antiarrhythmic activity.

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