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. 1975 Mar;12(1):79-82.
doi: 10.1136/jmg.12.1.79.

A family study of coeliac disease

T J David, A B Ajdukiewicz

A family study of coeliac disease

T J David et al. J Med Genet. 1975 Mar.

Abstract

Thirteen of 141 cases (9 percent) of overt, biopsy proven coeliac disease had a definitely affected relative. The pattern of inheritance in these families is compatible with an incompletely penetrant autosomal dominant gene. There was a female preponderance in the adults and the sporadic cases, but not in the children or the familial cases. The series included a pair of concordant and probably monozygotic twins. The authors believe that coeliac disease, as defined at present, is a heterogeneous condition.

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