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. 2001 Feb 3;357(9253):361-2.
doi: 10.1016/S0140-6736(00)03647-3.

Constitutively raised serum concentrations of mast-cell tryptase and severe anaphylactic reactions to Hymenoptera stings

D Ludolph-Hauser, F Ruëff, C Fries, P Schöpf, B Przybilla

Constitutively raised serum concentrations of mast-cell tryptase and severe anaphylactic reactions to Hymenoptera stings

D Ludolph-Hauser et al. Lancet. .

Abstract

Anaphylactic IgE-mediated reactions to Hymenoptera stings vary in their severity for reasons that are not clear. We investigated patients with a history of systemic anaphylatic reactions to honeybee or wasp stings. Nine (75%) of 12 patients with raised tryptase concentrations but only 28 (28%) of 102 patients with lower tryptase concentrations, had a history of severe sting reactions (p=0.004). Raised baseline serum concentrations of mast-cell tryptase and mastocytosis are potential risk factors for severe allergic reactions to Hymenoptera venom.

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Comment in

  • Hymenoptera stings and serum tryptase.
    Krishna MT, Fearby S, Annila I, Frew A. Krishna MT, et al. Lancet. 2001 May 12;357(9267):1527-8. doi: 10.1016/S0140-6736(00)04677-8. Lancet. 2001. PMID: 11383535 No abstract available.

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