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Case Reports
. 2001 Jan 27;357(9252):279-80.
doi: 10.1016/S0140-6736(00)03617-5.

Myoblast transplantation for heart failure

P Menasché, A A Hagège, M Scorsin, B Pouzet, M Desnos, D Duboc, K Schwartz, J T Vilquin, J P Marolleau
Case Reports

Myoblast transplantation for heart failure

P Menasché et al. Lancet. .

Abstract

Intramyocardial skeletal muscle transplantation has been shown experimentally to improve heart function after infarction. We report success with this procedure in a patient with severe ischaemic heart failure. We implanted autologous skeletal myoblasts into the postinfarction scar during coronary artery bypass grafting of remote myocardial areas. 5 months later, there was evidence of contraction and viability in the grafted scar on echocardiography and positron emission tomography. Although this result is encouraging, it requires validation by additional studies.

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