[The value of serum tissue polypeptide specific antigen TPS concentration in therapeutic monitoring of patients with epithelial malignant ovarian neoplasms]

Abstract

Design: The aim of this study was compare the concentrations TPS and CA 125 in serum 37 patients with ovarian carcinoma in order to evaluate the usefulness of markers in monitoring therapy.

Material and methods: The concentrations of TPS and CA 125 were determined prior to surgery, 1 week after surgery, prior chemotherapy, after 3 and 6 course chemotherapy next every 3 months for the first year and every 6 month for the next 2 years.

Results: The concentration of TPS decreased above cutoff values in all patients with remission after 3 course chemotherapy, CA 125 after 6 course chemotherapy. In patients with remission the increase of TPS preceded 3 to 12 months, of CA 125 1 to 3 month the reoccurence of the disease. In of patients with progressive disease the TPS levels decreased during therapy and next rise.

Conclusions: The current observations demonstrate that serial measurements of TPS appear to be useful for the evaluation of therapy and monitoring of patients.