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Review
. 2000;12(1-4):101-5.
doi: 10.1002/biof.5520120116.

Chemopreventive effects of coffee bean and rice constituents on colorectal carcinogenesis

H Mori  1 , K Kawabata, K Matsunaga, J Ushida, K Fujii, A Hara, T Tanaka, H Murai
Affiliations
Review

Chemopreventive effects of coffee bean and rice constituents on colorectal carcinogenesis

H Mori et al. Biofactors. 2000.

Abstract

Polyphenolic compound chlorogenic acid (CGA) known to be much contained in coffee beans was found to have a regressive effect on induced aberrant crypt foci (ACF) as well as on development of ACF in azoxymethane (AOM)-induced colorectal carcinogenesis in rats. Rice germ and gamma-aminobutyric acid-enriched defatted rice germ inhibited AOM-induced ACF formation and colorectal carcinogenesis in rats. Ferulic acid (FA) also known to be contained in coffee beans and rice prevented AOM-induced ACF formation and intestinal carcinogenesis in rats. Both of food factors, coffee and rice may be of benefit to prevention of human colorectal cancers.

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