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. 2001 Feb;49(2):257-60.
doi: 10.1002/1531-8249(20010201)49:2<257::aid-ana48>3.0.co;2-x.

14-3-3 protein cerebrospinal fluid detection in human growth hormone-treated Creutzfeldt-Jakob disease patients

J P Brandel  1 , K Peoc'h, P Beaudry, A Welaratne, C Bottos, Y Agid, J L Laplanche
Affiliations

14-3-3 protein cerebrospinal fluid detection in human growth hormone-treated Creutzfeldt-Jakob disease patients

J P Brandel et al. Ann Neurol. 2001 Feb.

Abstract

The usefulness of the detection of 14-3-3 protein in the cerebrospinal fluid (CSF) in the diagnosis of Creutzfeldt-Jakob disease transmitted from human growth hormone was evaluated in 20 French patients. The 14-3-3 protein was rarely detectable within the first 3 months of the disease but always positive after 7 months associated with the aggravation of the disease and the occurrence of dementia. 14-3-3 detection was not predictive of the survival time of the patients. The genotype at PRNP codon 129 could influence the timing of appearance of the 14-3-3 protein in the CSF.

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