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. 2001 Mar;85(3):287-90.
doi: 10.1136/bjo.85.3.287.

Reduced amplitude and delayed latency in foveal response of multifocal electroretinogram in early age related macular degeneration

J Li  1 , M O Tso, T T Lam
Affiliations

Reduced amplitude and delayed latency in foveal response of multifocal electroretinogram in early age related macular degeneration

J Li et al. Br J Ophthalmol. 2001 Mar.

Abstract

Aim: To explore the use of multifocal electroretinograms (MERG) in detecting early changes in age related macular degeneration (AMD).

Method: 15 pre-AMD or early AMD eyes showing retinal drusen or irregular fundus pigmentation with window defects by fluorescein angiography (FA) and mildly decreased visual acuity were examined and compared with their asymptomatic fellow eyes. 20 age matched normal eyes were included as controls. MERG was recorded by a Veris system (version 3.0) using a 103 hexagon stimulus and 218 second total recording time per eye. The first order kernel was used to calculate amplitudes and latencies in three configurations: the nasal and the temporal areas, the superior and the inferior areas, and six concentric rings centred on the fovea.

Results: There were no significant differences in the amplitudes and the latencies between the different regions (nasal versus temporal and superior versus inferior) of the retina as well as between the different groups of eyes (normal, pre-AMD or early AMD, and the asymptomatic fellow eyes) in each region. Using the concentric configuration, the foveal amplitude of pre-AMD or early AMD eyes was significantly suppressed when compared with the age matched control group and their average latency was longer in the fovea than in outer rings and significantly prolonged when compared with the normal control group. Similar changes in amplitude and latency were also observed in the asymptomatic fellow eyes.

Conclusion: Significant abnormality in the foveal amplitude and the foveal latency of MERG could be detected in pre-AMD or early AMD eyes as well as their asymptomatic contralateral eyes, suggesting MERG as a sensitive tool in detecting early foveal abnormalities in AMD.

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Figures

Figure 1
Figure 1
Configurations for the first kernel calculations of MERG. (Left) Nasal versus temporal retina. (Middle) Superior versus inferior retina. (Right) Concentric rings centring on the fovea.
Figure 2
Figure 2
Illustration of the MERG responses and their calculated P1 amplitudes and N1 latencies in (a) normal, (b) fellow, (c) and pre-AMD or early AMD eyes.
See this image and copyright information in PMC

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