Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2001 Mar;233(3):360-4.
doi: 10.1097/00000658-200103000-00009.

Familial adenomatous polyposis: prevalence of adenomas in the ileal pouch after restorative proctocolectomy

Y R Parc  1 , S Olschwang, B Desaint, G Schmitt, R G Parc, E Tiret
Affiliations

Familial adenomatous polyposis: prevalence of adenomas in the ileal pouch after restorative proctocolectomy

Y R Parc et al. Ann Surg. 2001 Mar.

Abstract

Objectives: To determine the prevalence of adenomas in ileal pouches from patients with familial adenomatous polyposis (FAP) and to determine whether a correlation exists between the presence of pouch adenomas and duodenal adenomas and the site of the adenomatous polyposis coli gene mutation.

Summary background data: Restorative proctocolectomy can markedly reduce the risk of colorectal adenocarcinoma in FAP patients. However, adenomas with the potential to progress to adenocarcinoma can develop in the duodenum, ileum, and continent ileostomy after restorative proctocolectomy. More recently, adenomas have been described in the ileal pouch after ileoanal anastomosis.

Methods: Pouch endoscopy was offered to 167 patients with FAP who had undergone restorative proctocolectomy between January 1984 and December 1996.

Results: Adenomas were found in 35% of the 85 ileal pouches examined. No invasive carcinomas were noted. The risk of developing one or more adenomas at 5, 10, and 15 years was 7%, 35%, and 75%, respectively. Patients with adenomas were more likely to have duodenal and ampullary adenomas. No correlation was detected between adenoma development and the site of the adenomatous polyposis coli mutation.

Conclusions: Adenomas are frequently found in the ileal pouch of patients after restorative proctocolectomy for FAP. Regular endoscopic surveillance of the pouch is recommended at a frequency similar to that of upper gastrointestinal endoscopy.

PubMed Disclaimer

Figures

None
Figure 1. Risk curve to develop adenoma of the pouch after restorative proctocolectomy with construction of an ileal reservoir.
See this image and copyright information in PMC

References

    1. Nakahara S, Itoh H, Iida M, et al. Ileal adenomas in familial polyposis coli. Dis Colon Rectum 1985; 28: 875–877. - PubMed
    1. Roth JA, Logio T. Carcinoma arising in an ileostomy stoma: an unusual complication of adenomatous polyposis coli. Cancer 1982; 49: 2180–2184. - PubMed
    1. Ross JE, Mara JE. Small bowel polyps and carcinoma in multiple intestinal polyposis. Arch Surg 1974; 108: 736–738. - PubMed
    1. Primrose JN, Quirke P, Johnston D. Carcinoma of the ileostomy in a patient with familial adenomatous polyposis. Br J Surg 1988; 75: 384. - PubMed
    1. Suarez V, Alexander-Williams J, O’Connor HJ, et al. Carcinoma developing in ileostomies after 25 or more years. Gastroenterology 1988; 95: 205–208. - PubMed

Publication types

MeSH terms