Neuroprotective aspects of a novel MAO-B inhibitor PF9601N
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- PMID: 11225513
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Neuroprotective aspects of a novel MAO-B inhibitor PF9601N
Neurobiology (Bp).
2000.
Abstract
PF9601N is an acetylenic tryptamine derivative devoid of amphetamine-like properties, that behaves as suicide MAO-B inhibitor more potent than l-deprenyl. It is highly selective towards MAO-B and it neuroprotects from the neurotoxicity induced in C57Bl/6 adult mice by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). PF9601N also shows in vitro antioxidant properties by inhibiting the dopamine autoxidation. A potential therapeutic use in Parkinson's disease treatment is proposed for this compound.
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