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. 2000;8(3-4):231-6.

Neuroprotective aspects of a novel MAO-B inhibitor PF9601N

V Pérez  1 , J Morón, M Pastó, M Unzeta
Affiliations
  • PMID: 11225513

Neuroprotective aspects of a novel MAO-B inhibitor PF9601N

V Pérez et al. Neurobiology (Bp). 2000.

Abstract

PF9601N is an acetylenic tryptamine derivative devoid of amphetamine-like properties, that behaves as suicide MAO-B inhibitor more potent than l-deprenyl. It is highly selective towards MAO-B and it neuroprotects from the neurotoxicity induced in C57Bl/6 adult mice by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). PF9601N also shows in vitro antioxidant properties by inhibiting the dopamine autoxidation. A potential therapeutic use in Parkinson's disease treatment is proposed for this compound.

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