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. 1999 Dec;1(4):203-6.

Chronic effect of endosulfan on the testicular functions of rat

K C Chitra  1 , C Latchoumycandane, P P Mathur
Affiliations
  • PMID: 11225895

Chronic effect of endosulfan on the testicular functions of rat

K C Chitra et al. Asian J Androl. 1999 Dec.

Abstract

Aim: To find out the toxic effect of endosulfan on the testicular function of pubertal rats.

Methods: Male rats of pubertal age were orally administered endosulfan at a dose of 1.0 mg/kg body weight for 30 days. Twenty-four hours after the last treatment, the rats were sacrificed and the testis, epididymis, seminal vesicles and ventral prostate were removed and weighed. A 10% testicular homogenate was prepared for biochemical estimations.

Results: In endosulfan-treated rats, there were a reduction in the body weight and the weights of testis and accessory sex organs, a decrease in the testicular lactate and pyruvate activities, and in the testicular DNA and RNA concentrations, whereas the testicular protein concentration was slightly increased; the specific activity of testicular steroidogenic enzyme, 3beta-OH-steroid dehydrogenase and the ascorbic acid level were decreased, which were correlated with a decrease in steroidogenesis. The lysosomal enzyme acid phosphatase and brush-border enzyme alkaline phosphatase activities were also decreased in the testis of treated rats.

Conclusion: In pubertal rats, endosulfan treatment inhibits the testicular functions.

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