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. 2001 Mar;37(3):544-9.
doi: 10.1053/ajkd.2001.22078.

Urea reduction ratio that considers effects of ultrafiltration and intradialytic urea generation

Y L Cheng  1 , K S Choi, K F Chau, C S Li, C U Yung, A W Yu, K K Wong
Affiliations

Urea reduction ratio that considers effects of ultrafiltration and intradialytic urea generation

Y L Cheng et al. Am J Kidney Dis. 2001 Mar.

Abstract

We modified the urea reduction ratio (URR) equation to correct the effects of ultrafiltration and intradialytic urea generation on the delivered dose of hemodialysis: mURR = [1 - (R/1 + 2*UF/BW) + 0.01*t] x 100% where mURR is modified URR, R is postdialysis plasma urea nitrogen (PUN) to predialysis PUN ratio, UF is ultrafiltrate volume in liters, BW is postdialysis body weight in kilograms, and t is dialysis session length in hours. The equation was validated against 145 hemodialysis treatments on 33 stable maintenance dialysis patients. The mURR values obtained closely predicted single-pool Kt/V (spKt/V) values. In contrast to conventional URR, the range of spKt/V values at each mURR value is narrow over a wide range of UF, t, and R values. Based on the mURR equation, mURR values of 64%, 70%, and 76% are mathematically equivalent to spKt/V levels of 1.0, 1.2, and 1.4, respectively. This equation can be a useful bedside tool to quantify hemodialysis dose.

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