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Review
. 2001 Feb 6;164(3):353-5.

New insights into the physiology and pharmacology of vitamin C

S J Padayatty  1 , M Levine
Affiliations
Review

New insights into the physiology and pharmacology of vitamin C

S J Padayatty et al. CMAJ. .
No abstract available

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Figures

None
Fig. 1: Ascorbic acid (AA) transport, dehydroascorbic acid (DHA) transport and recycling in human neutrophils. AA, transported by sodium-dependent vitamin C transporters (SVCT), maintains mmol/L concentrations of AA inside neutrophils. Activated neutrophils secrete reactive oxygen species that oxidize extracellular AA to DHA. DHA is rapidly transported into the neutrophil by the glucose transporters GLUT1 and GLUT3 and immediately reduced to AA by glutaredoxin (GRX), producing a 10-fold increase in neutrophil internal AA concentration. Glutathione (GSH), used during DHA reduction, is regenerated from glutathione disulfide (GSSG) by glutathione reductase (GRD) and NADPH. NADPH is a product of glucose metabolism through the pentose phosphate pathway. As NADPH is oxidized to NADP, electrons are transferred to GRD so it can reduce GSSG to GSH. Modified and reproduced with permission of the Journal of Nutritional Biochemistry 1998;9:120, Elsevier Sciences Inc.
See this image and copyright information in PMC

Comment in

  • A cure for miracles.
    [No authors listed] [No authors listed] CMAJ. 2001 Feb 6;164(3):317, 319. CMAJ. 2001. PMID: 11232126 Free PMC article. No abstract available.
  • Exploring the actions of vitamin C.
    Das UN. Das UN. CMAJ. 2001 Jul 10;165(1):13-4. CMAJ. 2001. PMID: 11468945 Free PMC article. No abstract available.

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