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. 2001 Feb 15;71(3):477-9.
doi: 10.1097/00007890-200102150-00023.

Rapid decline of antibodies after hepatitis A immunization in liver and renal transplant recipients

M Günther  1 , K Stark, R Neuhaus, P Reinke, K Schröder, U Bienzle
Affiliations

Rapid decline of antibodies after hepatitis A immunization in liver and renal transplant recipients

M Günther et al. Transplantation. .

Abstract

Background: Hepatitis A vaccine is safe and achieves good seroconversion rates in liver (LTX) and renal (RTX) transplant recipients.

Methods: A study was performed to determine the anti-hepatitis A virus (HAV) antibody decline in LTX and RTX patients, and in healthy controls who have been immunized with two doses of hepatitis A vaccine.

Results: LTX and RTX patients had a satisfactory seroconversion rate after complete immunisation. However, 2 years later they had experienced a much more rapid antibody decline than controls, and only 59% of LTX and 26% of RTX seroconverters showed titres above the cut-off level defined as protective.

Conclusions: Patients on immunosuppressive therapy may not be adequately protected against hepatitis A a few years after vaccination and alternative vaccination schemes may have to be considered.

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