[Serum lipoproteids and ketone bodies after constant infusion of sorbitol i.v. (author's transl)]

Abstract

20 patients of a metabolic ward received a six-hour infusion of sorbitol at a dosis of 0.125 g/kg/h(n equal to 10) and 0.25 g/kg/h(n equal to 10) body weight. Cholesterol levels showed a significant fall in both groups (p smaller than 0.05) and triglycerides rose significantly (p smaller than 0.05). The concentrations of acetoacetate and beta-hydroxybutyrate were lowered irrespective of the dosis. The cholesterol-reducing effect can be explained by the antiketogenic action, whereas the increase in triglycerides possibly could be the result of raised alpha-glycerophosphate.