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. 2001 Feb;29(2):441-52.
doi: 10.1016/s0896-6273(01)00217-3.

Electrical activity modulates growth cone guidance by diffusible factors

G Ming  1 , J Henley, M Tessier-Lavigne, H Song, M Poo
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Free article

Electrical activity modulates growth cone guidance by diffusible factors

G Ming et al. Neuron. 2001 Feb.
Free article

Abstract

Brief periods of electrical stimulation of cultured Xenopus spinal neurons resulted in a marked alteration in the turning responses of the growth cone induced by gradients of attractive or repulsive guidance cues. Netrin-1-induced attraction was enhanced, and the repulsion induced by myelin-associated glycoprotein (MAG) or myelin membrane fragments was converted to attraction. The effect required the presence of extracellular Ca(2+) during electrical stimulation and appeared to be mediated by an elevation of both cytoplasmic Ca(2+) and cAMP. Thus, electrical activity may influence the axonal path finding of developing neurons, and intermittent electrical stimulation may be effective in promoting nerve regeneration after injury.

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  • Stimulating new turns.
    Harris B, Holt C. Harris B, et al. Neuron. 2001 Feb;29(2):311-2. doi: 10.1016/s0896-6273(01)00203-3. Neuron. 2001. PMID: 11239420 No abstract available.

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