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. 2001 Mar;131(3):392-4.
doi: 10.1016/s0002-9394(00)00800-x.

Silicone oil-associated optic nerve degeneration

M Budde  1 , C Cursiefen, L M Holbach, G O Naumann
Affiliations

Silicone oil-associated optic nerve degeneration

M Budde et al. Am J Ophthalmol. 2001 Mar.

Abstract

Purpose: To report the frequency and extent of silicone oil migration into the optic nerve during silicone oil endotamponade.

Methods: Histopathologic analysis of 74 eyes enucleated after silicone oil endotamponade.

Results: In 14 of 74 enucleated eyes (24%), optically empty vacuoles regarded as silicone oil vacuoles were observed in the retrolaminar optic nerve. In three eyes, silicone oil in the optic nerve was surrounded by a granulomatous inflammatory reaction. In serial cross sections, the vacuoles extended up to the line of surgical transsection (up to 9 mm) of the optic nerve and constituted up to 40% of the total cross-sectional area.

Conclusions: After silicone oil endotamponade, silicone oil may replace a considerable amount of tissue of the retrolaminar optic nerve. A granulomatous inflammatory reaction surrounding silicone oil may add to optic nerve damage.

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Comment in

  • Silicone oil-associated optic nerve degeneration.
    Agrawal R, Soni M, Biswas J, Sharma T, Gopal L. Agrawal R, et al. Am J Ophthalmol. 2002 Mar;133(3):429-30. doi: 10.1016/s0002-9394(01)01300-9. Am J Ophthalmol. 2002. PMID: 11860994 No abstract available.

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