[Calcification of thrombus associated with central venous catheter: unusual complication]

Abstract

Thrombosis originating from the tip of central venous catheter is a well known complication. The calcification of such a thrombus is very rare. Until now, only two cases had been described with long-term indwelling central venous catheters used for total parenteral nutrition. We report the first case of a calcified thrombus occurred during a short-term central venous catheterisation. The presumptive mechanism of thrombus calcification is precipitation of calcium salts and its deposition on a pre-existent thrombus. In total parenteral nutrition the mechanism of calcification seems to be multifactorial. Thus, the precipitation of calcium phosphate is increased by the following factors: higher calcium and phosphate concentrations, the use of calcium chloride instead of calcium gluconate, lower pH solutions, slow infusion rate.