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Review
. 2000 Oct-Nov;50(1-2):109-20.
doi: 10.1023/a:1006416003964.

VEGF in brain tumors

M R Machein  1 , K H Plate
Affiliations
Review

VEGF in brain tumors

M R Machein et al. J Neurooncol. 2000 Oct-Nov.

Abstract

Vascular endothelial growth factor (VEGF) is a regulator of angiogenesis, vasculogenesis and vascular permeability. In this contribution, molecular and biological properties of VEGF are described. Furthermore, this article focuses on the evidence that angiogenesis in brain tumors is mediated by VEGF. Among the topics discussed are expression patterns of VEGF and its receptors in different brain tumors, possible regulatory mechanism involved in the VEGF-driven tumor angiogenesis and the involvement of VEGF in the genesis of peritumoral edema. Finally, anti-angiogenesis approaches to target VEGF/VEGF receptors are discussed.

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References

    1. Acta Neuropathol. 1999 Oct;98(4):414-20 - PubMed
    1. Neurosurg Clin N Am. 1994 Apr;5(2):201-15 - PubMed
    1. Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8761-6 - PubMed
    1. Cell Growth Differ. 1998 Jan;9(1):49-58 - PubMed
    1. Lab Invest. 1992 Oct;67(4):529-34 - PubMed

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