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Review
. 2001 Mar;26(3):174-9.
doi: 10.1016/s0968-0004(00)01780-1.

The world according to PARP

S Smith  1
Affiliations
Review

The world according to PARP

S Smith. Trends Biochem Sci. 2001 Mar.

Abstract

An immediate cellular response to DNA damage is the synthesis of poly(ADP-ribose) by the enzyme poly(ADP-ribose) polymerase (PARP). This nuclear enzyme and the unique post-translational modification it catalyzes have long been considered to function exclusively in cellular surveillance of genotoxic stress. The recent identification of multiple members of a PARP family might force a revision of this concept. The novel primary structures and subcellular localizations for some of these PARPs suggests new and unexpected roles for poly(ADP-ribosyl)ation in telomere replication and cellular transport.

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