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. 1999 Nov;63(Pt 6):535-8.
doi: 10.1017/S0003480099007824.

Hardy-Weinberg quality control

I Gomes  1 , A Collins, C Lonjou, N S Thomas, J Wilkinson, M Watson, N Morton
Affiliations

Hardy-Weinberg quality control

I Gomes et al. Ann Hum Genet. 1999 Nov.

Abstract

An efficient test of deviation from Hardy-Weinberg frequencies with one degree of freedom was applied to 44 marker loci in a genome scan, and 7 loci had a significant excess of apparent homozygotes (chi2 (1) > 6) suggestive of typing error. In this example evidence for linkage did not increase when outliers were censored. Statistical quality control is an essential part of genotyping, and the effect of mistyping and map error should be considered in evaluating any genome scan.

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