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. 2001 Mar 3;357(9257):686-7.
doi: 10.1016/s0140-6736(00)04138-6.

CD36 deficiency associated with insulin resistance

K Miyaoka, T Kuwasako, K Hirano, S Nozaki, S Yamashita, Y Matsuzawa

CD36 deficiency associated with insulin resistance

K Miyaoka et al. Lancet. .

Abstract

No major genes responsible for insulin resistance have yet been identified. CD36 is a multifunctional receptor, which plays a part in mediating intracellular signalling as well as in taking up biologically active substances such as long-chain fatty acids. We looked for insulin resistance in genetic CD36 deficiency, which is common in Asian and African populations. The euglycaemic hyperinsulinaemic clamp technique showed insulin resistance in the five CD36-deficient people tested. We conclude that CD36 could be responsible for insulin resistance.

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  • CD36, insulin resistance, and coronary heart disease.
    Aitman TJ. Aitman TJ. Lancet. 2001 Mar 3;357(9257):651-2. doi: 10.1016/S0140-6736(00)04149-0. Lancet. 2001. PMID: 11247544 No abstract available.
  • CD36 deficiency and insulin resistance.
    Petrie JR, Collison M, Connell JM, Gould GW, Dominiczak AF. Petrie JR, et al. Lancet. 2001 Jul 21;358(9277):242-3; author reply 244. doi: 10.1016/S0140-6736(01)05428-9. Lancet. 2001. PMID: 11480435 No abstract available.
  • CD36 deficiency and insulin resistance.
    Chiba H, Yanai H, Fujiwara H, Matsuno K, Kobayashi K. Chiba H, et al. Lancet. 2001 Jul 21;358(9277):243-4; author reply 244. doi: 10.1016/S0140-6736(01)05430-7. Lancet. 2001. PMID: 11480436 No abstract available.
  • CD36 deficiency and insulin resistance.
    Iizuka Y, Gotoda T, Ishibashi S, Yamada N. Iizuka Y, et al. Lancet. 2001 Jul 21;358(9277):243; author reply 244. doi: 10.1016/S0140-6736(01)05429-0. Lancet. 2001. PMID: 11480437 No abstract available.

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