Evidence for the inactivation of an X chromosome early in the development of the human female
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- PMCID: PMC1762755
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Evidence for the inactivation of an X chromosome early in the development of the human female
Am J Hum Genet.
1975 Mar.
Abstract
Studies of somatic tissues and cultured cells, including fibroblast clones, from human embryos heterozygous for the electrophoretic variants of glucose-6-phosphate dehydrogenase confirm that one X chromosome is inactivated very early in embryonic development and indicate that X inactivation has occurred in the majority of cells from a variety of tissues at least by 5 weeks from conception.
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