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. 1975 Mar;27(2):233-9.

Evidence for the inactivation of an X chromosome early in the development of the human female

B R Migeon, J F Kennedy

Evidence for the inactivation of an X chromosome early in the development of the human female

B R Migeon et al. Am J Hum Genet. 1975 Mar.

Abstract

Studies of somatic tissues and cultured cells, including fibroblast clones, from human embryos heterozygous for the electrophoretic variants of glucose-6-phosphate dehydrogenase confirm that one X chromosome is inactivated very early in embryonic development and indicate that X inactivation has occurred in the majority of cells from a variety of tissues at least by 5 weeks from conception.

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References

    1. Am J Hum Genet. 1971 Mar;23(2):199-210 - PubMed
    1. Nature. 1971 Jun 11;231(5302):385-6 - PubMed
    1. Am J Clin Pathol. 1972 Apr;57(4):534-6 - PubMed
    1. Cell Differ. 1972 Oct;1(4):215-8 - PubMed
    1. Biochem Genet. 1973 Jun;9(2):163-8 - PubMed

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