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Review
. 2001 Apr;13(2):225-31.
doi: 10.1016/s0955-0674(00)00201-5.

DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

D Durocher  1 , S P Jackson
Affiliations
Review

DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

D Durocher et al. Curr Opin Cell Biol. 2001 Apr.

Abstract

The DNA damage signalling pathway is a core element of the cellular response to genotoxic insult, and its components play key roles in defending against neoplastic transformation. Recent work has indicated that the human ATM and ATR proteins, and their yeast homologues, are intimately involved in sensing DNA damage, suggesting parallels with the DNA double-strand break repair enzyme DNA-PK.

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