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. 2001 Feb;9(2):503-10.
doi: 10.1016/s0968-0896(00)00257-1.

Cysteinyl peptide inhibitors of Bacillus cereus zinc beta-lactamase

S Bounaga  1 , M Galleni, A P Laws, M I Page
Affiliations

Cysteinyl peptide inhibitors of Bacillus cereus zinc beta-lactamase

S Bounaga et al. Bioorg Med Chem. 2001 Feb.

Abstract

Several cysteinyl peptides have been synthesised and shown to be reversible competitive inhibitors of the Bacillus cereus metallo-beta-lactamase. The pH dependence of pKi indicates that the thiol anion displaces hydroxide ion from the active site zinc(II). D,D-Peptides bind to the enzyme better than other diastereoisomers, which is compatible with the predicted stereochemistry of the active site.

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