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Review
. 2000 Dec;1(4):449-51.

PNU-142731A Pharmacia

G Dent  1
Affiliations
  • PMID: 11249698
Review

PNU-142731A Pharmacia

G Dent. Curr Opin Investig Drugs. 2000 Dec.

Abstract

Pharmacia is developing PNU-142731A, a potential lead compound as a treatment for asthma [294718]. It is in phase I clinical trials. PNU-142731A is a potent inhibitor of eosinophilic lung inflammation in rodents, and shows a good bioavailability profile in animals; the mechanism of action is being investigated. Unlike the original compound PNU-104067F, PNU-142731A does not give rise to gall bladder toxicity [295987], [298023].

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