Review
doi: 10.1016/s0959-437x(00)00170-2.
The ins and outs of nucleosome assembly
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- PMID: 11250135
- DOI: 10.1016/s0959-437x(00)00170-2
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Review
The ins and outs of nucleosome assembly
Curr Opin Genet Dev.
2001 Apr.
Abstract
De novo nucleosome assembly coupled to DNA replication and repair in vitro involves the histone chaperone chromatin assembly factor 1 (CAF-1). Recent studies support a model in which CAF-1 can be targeted to newly synthesized DNA through a direct interaction with proliferating cell nuclear antigen (PCNA) and can act synergistically with a newly identified histone chaperone. Insights have also been obtained into mechanisms by which this CAF-1-dependent pathway can establish a repressed chromatin state.
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