Review
doi: 10.1016/s0959-437x(00)00173-8.
Histone acetyltransferases: function, structure, and catalysis
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- PMID: 11250138
- DOI: 10.1016/s0959-437x(00)00173-8
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Review
Histone acetyltransferases: function, structure, and catalysis
Curr Opin Genet Dev.
2001 Apr.
Abstract
Histone acetyltransferases (HATs) directly link chromatin modification to gene activation. Recent structure/function studies provide insights into HAT catalysis and histone binding, and genetic studies suggest cross-talk between acetylation and other histone modifications. Developmental aberrations in mice and certain human cancers are associated with HAT mutations, further highlighting the importance of these enzymes to normal cell growth and differentiation.
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