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Review
. 2001 Apr;11(2):162-6.
doi: 10.1016/s0959-437x(00)00174-x.

Functional significance of histone deacetylase diversity

S Khochbin  1 , A Verdel, C Lemercier, D Seigneurin-Berny
Affiliations
Free article
Review

Functional significance of histone deacetylase diversity

S Khochbin et al. Curr Opin Genet Dev. 2001 Apr.
Free article

Abstract

Nucleocytoplasmic shuttling of histone deacetylases is emerging as a major step in determining the composition, and hence the activity, of the corresponding nuclear regulatory complexes. This shuttling process is one of the distinctive characteristics of these enzymes, themselves belonging to structurally and functionally different classes. Considering the specific features of each class of deacetylases, it is possible to determine how each member can contribute to particular cellular functions.

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