Review
doi: 10.1016/s0960-9822(01)00057-4.
Replication checkpoint: preventing mitotic catastrophe
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- PMID: 11250164
- DOI: 10.1016/s0960-9822(01)00057-4
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Review
Replication checkpoint: preventing mitotic catastrophe
Curr Biol.
.
Free article
Abstract
A conserved network of signal transduction pathways prevents mitosis if DNA is damaged or its synthesis incomplete. Loss of this checkpoint control is detrimental to the developing embryo. Recent studies have shed new light on how the essential ATR and Chk1 protein kinases cooperate to prevent such a crisis.
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