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. 2001 Apr;85(4):458-62.
doi: 10.1136/heart.85.4.458.

Increased risk for ischaemic events is related to combined RAS polymorphism

P P van Geel  1 , Y M Pinto, A H Zwinderman, R H Henning, A J van Boven, J W Jukema, A V Bruschke, J J Kastelein, W H van Gilst
Affiliations

Increased risk for ischaemic events is related to combined RAS polymorphism

P P van Geel et al. Heart. 2001 Apr.

Abstract

Objective: To determine whether the angiotensin converting enzyme (ACE) and the angiotensin II type 1 receptor (AT(1)R A1166C) gene polymorphism interact to increase the risk of ischaemic events, and whether this can be explained by the progression of angiographically defined coronary atherosclerosis.

Design: Prospective defined substudy of the lipid lowering regression trial (REGRESS).

Setting: University hospital.

Patients: 885 male patients with stable coronary artery disease.

Main outcome measures: Incidence of ischaemic events during a two year follow up; serial quantitative coronary arteriography (mean segment diameter and minimum obstruction diameter) at baseline and after two years.

Results: Patients who carried both the ACE-DD and AT(1)R-CC genotype had significantly more ischaemic events during the two year follow up than those carrying other genotype combinations (p = 0.035, Mantel-Haenszel test for linear association). There was no association between the two genotypes and mean segment diameter or minimum obstruction diameter at baseline or after two years.

Conclusions: The suggestion that ACE-DD and AT(1)R-CC genotypes interact to increase the risk of ischaemic events is confirmed. However, this increased risk was not accompanied by increased progression of angiographically defined coronary atherosclerosis.

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Figures

Figure 1
Figure 1
Kaplan-Meier curves for the event-free survival of patients according to ACE-DD and AT1R-CC genotypes. The p value indicates the overall significance of the Mantel-Haenszel test for linear association between the curves.
See this image and copyright information in PMC

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