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Review
. 2000 Dec;1(3):169-78.
doi: 10.1038/35043051.

How cells read TGF-beta signals

J Massagué  1
Affiliations
Review

How cells read TGF-beta signals

J Massagué. Nat Rev Mol Cell Biol. 2000 Dec.

Abstract

Cell proliferation, differentiation and death are controlled by a multitude of cell-cell signals, and loss of this control has devastating consequences. Prominent among these regulatory signals is the transforming growth factor-beta (TGF-beta) family of cytokines, which can trigger a bewildering diversity of responses, depending on the genetic makeup and environment of the target cell. What are the networks of cell-specific molecules that mould the TGF-beta response to each cell's needs?

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