Quantitative trait loci in Drosophila
- PMID: 11253063
- DOI: 10.1038/35047544
Quantitative trait loci in Drosophila
Abstract
Phenotypic variation for quantitative traits results from the simultaneous segregation of alleles at multiple quantitative trait loci. Understanding the genetic architecture of quantitative traits begins with mapping quantitative trait loci to broad genomic regions and ends with the molecular definition of quantitative trait loci alleles. This has been accomplished for some quantitative trait loci in Drosophila. Drosophila quantitative trait loci have sex-, environment- and genotype-specific effects, and are often associated with molecular polymorphisms in non-coding regions of candidate genes. These observations offer valuable lessons to those seeking to understand quantitative traits in other organisms, including humans.
Similar articles
-
The genetic architecture of quantitative traits: lessons from Drosophila.Curr Opin Genet Dev. 2004 Jun;14(3):253-7. doi: 10.1016/j.gde.2004.04.003. Curr Opin Genet Dev. 2004. PMID: 15172667 Review.
-
Shuttle craft: a candidate quantitative trait gene for Drosophila lifespan.Aging Cell. 2004 Oct;3(5):297-307. doi: 10.1111/j.1474-9728.2004.00114.x. Aging Cell. 2004. PMID: 15379853
-
The nature of quantitative genetic variation revisited: lessons from Drosophila bristles.Bioessays. 1996 Feb;18(2):113-21. doi: 10.1002/bies.950180207. Bioessays. 1996. PMID: 8851044 Review.
-
Environment-influenced expression of polygene mutations isolated from a natural population of Drosophila melanogaster.Genetica. 1998;102-103(1-6):217-28. Genetica. 1998. PMID: 9720281
-
Quantitative trait loci affecting natural variation in Drosophila longevity.Mech Ageing Dev. 2004 Mar;125(3):179-89. doi: 10.1016/j.mad.2003.12.008. Mech Ageing Dev. 2004. PMID: 15013662
Cited by
-
Assessment of the genomic variation in a cattle population by re-sequencing of key animals at low to medium coverage.BMC Genomics. 2013 Jul 4;14:446. doi: 10.1186/1471-2164-14-446. BMC Genomics. 2013. PMID: 23826801 Free PMC article.
-
Gene expression clines reveal local adaptation and associated trade-offs at a continental scale.Sci Rep. 2016 Sep 7;6:32975. doi: 10.1038/srep32975. Sci Rep. 2016. PMID: 27599812 Free PMC article.
-
Shared Genomic Regions Underlie Natural Variation in Diverse Toxin Responses.Genetics. 2018 Dec;210(4):1509-1525. doi: 10.1534/genetics.118.301311. Epub 2018 Oct 19. Genetics. 2018. PMID: 30341085 Free PMC article.
-
The DSC1 channel, encoded by the smi60E locus, contributes to odor-guided behavior in Drosophila melanogaster.Genetics. 2002 Aug;161(4):1507-16. doi: 10.1093/genetics/161.4.1507. Genetics. 2002. PMID: 12196396 Free PMC article.
-
Polygenic mutation in Drosophila melanogaster: Mapping spontaneous mutations affecting sensory bristle number.Genetics. 2005 Aug;170(4):1723-35. doi: 10.1534/genetics.104.032581. Epub 2005 Jun 8. Genetics. 2005. PMID: 15944368 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
