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Comment
. 2001 Apr;68(4):1065-7.
doi: 10.1086/319525.

Correcting for a potential bias in the pedigree disequilibrium test

E R Martin, M P Bass, N L Kaplan
Comment

Correcting for a potential bias in the pedigree disequilibrium test

E R Martin et al. Am J Hum Genet. 2001 Apr.
No abstract available

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Figures

Figure 1
Figure 1
Pedigrees illustrating PDT bias. Black circles denote affected individuals and white squares denote unaffected individuals. Disease- and marker-locus genotypes are shown for each individual. Values of quantities from equation (1) are given for each pedigree.
See this image and copyright information in PMC

Comment on

References

Electronic-Database Information

    1. Duke Center for Human Genetics, The, http://wwwchg.mc.duke.edu/ (software for conducting PDT-avg and PDT-sum analyses)

References

    1. Abecasis GR, Cookson WOC, Cardon LR (2000) Pedigree tests of transmission disequilibrium. Eur J Hum Genet 8:545–551 - PubMed
    1. Martin ER, Kaplan NL, Weir BS (1997) Tests for linkage and association in nuclear families. Am J Hum Genet 61:439–448 - PMC - PubMed
    1. Martin ER, Monks SA, Warren LL, Kaplan NL (2000) A test for linkage and association in general pedigrees: the pedigree disequilibrium test. Am J Hum Genet 67:146–154 - PMC - PubMed
    1. Rabinowitz D, Laird N (2000) A unified approach to adjusting association tests for population admixture with arbitrary pedigree structure and arbitrary missing marker information. Hum Hered 50:211–223 - PubMed
    1. Teng J, Risch N (1999) The relative power of family-based and case-control designs for linkage disequilibrium studies of complex human diseases. II. Individual genotyping. Genome Res 9:234–241 - PubMed

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