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. 1975 Jan;53(1):152-4.
doi: 10.1111/j.1476-5381.1975.tb07344.x.

Kinetics and some characteristics of uptake of noradrenaline by the human umbilical artery

O D Gulati, N Sivaramakrishna

Kinetics and some characteristics of uptake of noradrenaline by the human umbilical artery

O D Gulati et al. Br J Pharmacol. 1975 Jan.

Abstract

The uptake of exogenously added noradrenaline (NA) (0.5-2.5 mug/ml) by the human umbilical artery was linear with time up to 10 minutes. The uptake was saturable and could be described by the Michaelis-Menten equation. The uptake was cocaine-resistant, normetanephrine-sensitive, was considerably inhibited in the cold and was partially inhibited by Na+- deficiency. Of NA accumulated in the artery 31% could be washed out by NA-free medium. It is concluded that the mechanism of uptake of NA by the human umbilical artery is similar to the uptake2 mechanism.

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