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Case Reports
. 2001 Mar;137(3):309-10.

Icodextrin cutaneous hypersensitivity: report of 3 psoriasiform cases

A Valance  1 , B Lebrun-Vignes, V Descamps, G Queffeulou, B Crickx
Affiliations
  • PMID: 11255330
Case Reports

Icodextrin cutaneous hypersensitivity: report of 3 psoriasiform cases

A Valance et al. Arch Dermatol. 2001 Mar.

Abstract

Background: Icodextrin is proposed as a new osmotic agent for use in peritoneal dialysis. Because of its recent use, adverse reactions are not well known. Cutaneous adverse effects have been described. We report 3 cases of cutaneous hypersensitivity to icodextrin and discuss the pathogenesis of this reaction.

Observations: The cutaneous adverse reaction was psoriasiform in our 3 cases. The eruption was generalized with acute generalized exanthematous pustulosis in 1 case, and limited to the palms and soles in 1 case. It occurred 10 to 15 days after icodextrin therapy was initiated. In patient 1, the results of a rechallenge with icodextrin were positive. Icodextrin therapy was discontinued in all patients.

Conclusions: Some cases of cutaneous reactions to icodextrin have been reported in the literature, but they are rare. As in our cases, most eruptions are psoriasiform, limited to the palms and soles, or extensive. Although the etiology is unclear, a hypersensitivity reaction, with the formation of immunocomplexes, is probable.

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