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Review
. 2001 Mar 19;193(6):F23-6.
doi: 10.1084/jem.193.6.f23.

Inflammatory cells and cancer: think different!

L M Coussens, Z Werb
Review

Inflammatory cells and cancer: think different!

L M Coussens et al. J Exp Med. .
No abstract available

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Figures

Figure 1
Figure 1
Tumors consist of neoplastic epithelial cells and their microenvironment. ECM in and around the forming tumor is populated with capillaries and their support cells (pericytes, smooth muscle cells, and fibroblasts), and inflammatory cells (macrophages, PMNs, and mast cells).
Figure 2
Figure 2
Epithelial-stromal cross-talk during neoplastic progression. Epithelial neoplasia is initiated with mutational events; however, these cells remain dormant until wounding or tumor promoters activate the quiescent stromal cells. These promotion events recruit and activate inflammatory cells such as PMNs, macrophages (Mφ), or mast cells (MCs). In turn, these activated inflammatory cells stimulate growth and progression of the epithelial cells to form a benign tumor. These cells further activate additional inflammation and the ensuing angiogenesis, ECM remodeling. This altered microenvironment further destabilizes the epithelial cells to undergo malignant conversion to full carcinomas and facilitate metastasis.
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References

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