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. 2001 Mar 1;6(6):293-302.
doi: 10.1016/s1359-6446(01)01684-1.

In vivo pharmacokinetics and pharmacodynamics in drug development using positron-emission tomography

E O. Aboagye  1 , P M. Price, T Jones
Affiliations

In vivo pharmacokinetics and pharmacodynamics in drug development using positron-emission tomography

E O. Aboagye et al. Drug Discov Today. .

Abstract

Positron-emission tomography (PET) is a sensitive technique that can be used to measure drug pharmacokinetics and pharmacodynamics non-invasively in target tissues of patients. Here we focus on the application of this technology to address some of the bottlenecks in drug development, including: elucidation of pathophysiology, evaluation of pharmacokinetics, proof of principle of mechanism, and assessment of efficacy and/or response to therapy.

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