Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2001 Feb;2(2):91-5.
doi: 10.1093/embo-reports/kve029.

The 'double lives' of membrane lipids. Workshop: Anno 2000. A lipid milestone

J A Killian  1 , G van Meer
Affiliations

The 'double lives' of membrane lipids. Workshop: Anno 2000. A lipid milestone

J A Killian et al. EMBO Rep. 2001 Feb.
No abstract available

PubMed Disclaimer

Figures

None
Fig. 1. Monolayer set-up as used by Gorter and Grendel (1925). A lipid extract of erythrocytes was spread at the lipid–water interface in a Langmuir trough, after which the lipids were compressed by a floating barrier. The point at which the surface layer offered resistance was interpreted as the point at which a closely packed monolayer was formed. This area was twice the calculated surface area of the erythrocytes from which the lipids had been extracted, which led to the first lipid bilayer model.
None
Fig. 2. Sphingolipid/cholesterol rafts make thick membranes. A domain (orange) of tall sphingolipids (long thin green barrels) and cholesterol (short green barrel) surrounded by stocky unsaturated PC (thick green barrels in blue environment) in the outer monolayer, potentially complemented by phosphatidylserine/cholesterol rafts (yellow) in PE (green) on the cytosolic side of a mammalian plasma membrane. The depicted domain contains ∼700 lipid molecules in each leaflet and has a thickness of ∼50 Å versus a thickness of ∼40 Å for the bulk membrane.
None
The authors* and organizers+ from left to right are: J.A.F. Op den Kamp+ and B. de Kruijff, G. van Meer* and J.A. Killian*.
None
The Anno 2000 membrane lipid workshop was organized by J.A.F. Op den Kamp and B. de Kruijff, and was held at Utrecht University (Utrecht, The Netherlands) October 26–28, 2000.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Bogdanov M. and Dowhan, W. (1999) Lipid-assisted protein folding. J. Biol. Chem., 274, 36827–36830. - PubMed
    1. de Kruijff B. (1997) Biomembranes. Lipids beyond the bilayer. Nature, 386, 129–130. - PubMed
    1. Gorter E. and Grendel, J. (1925) On bimolecular layers of lipoids on the chromocytes of blood. J. Exp. Med., 41, 439–443. - PMC - PubMed
    1. Kawai H. et al. (2001) Mice expressing only monosialoganglioside GM3 exhibit lethal audiogenic seizures. J. Biol. Chem., 276, in press. - PubMed
    1. Radhakrishnan A., Anderson, T.G., and McConnell, H.M. (2000) Condensed complexes, rafts, and the chemical activity of cholesterol in membranes. Proc. Natl Acad. Sci. USA, 97, 12422–12427. - PMC - PubMed

Publication types