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. 1975 Jan-Feb;2(1):17-21.
doi: 10.1111/j.1440-1681.1975.tb02369.x.

Pressure-flow relationships in the peripheral circulation of the dog with practolol

J F Green, J D Moore, E S Attix, R Zelis

Pressure-flow relationships in the peripheral circulation of the dog with practolol

J F Green et al. Clin Exp Pharmacol Physiol. 1975 Jan-Feb.

Abstract

1. The influence of practolol (a proposed beta1-adrenoreceptor antagonist) upon the pressure-flow relationships in the peripheral circulation was studied in eight anaesthetized dogs during right heart by-pass procedures. 2. Practool (1 mg/kg) produced a significant increase in the resistance to venous return which resulted in a significant fall in venous return. 3. There was no significant change in arterial resistance. 4. This study suggests that practolol should not be classified as an exclusive cardioselective beta-adrenoreceptor antagonist.

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