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Clinical Trial
. 1979 May 25;63(2):125-9.
doi: 10.1007/BF00429689.

Inhibition of 5-hydroxytryptamine reuptake by amitryptyline an zimelidine and its relationship to their therapeutic action

A Coppen, V A Rama Rao, C Swade, K Wood
Clinical Trial

Inhibition of 5-hydroxytryptamine reuptake by amitryptyline an zimelidine and its relationship to their therapeutic action

A Coppen et al. Psychopharmacology (Berl). .

Abstract

Amitriptyline and zimelidine significantly reduce the uptake of 5-HT into the blood platelets of depressive patients. The degree of inhibition is significantly correlated with the plasma drug level of amitriptyline. No significant relationship could be detected between the degree of inhibition of uptake and therapeutic outcome. The accepted mode of action of tricyclic antidepressant drugs and the deficiency hypotheses of affective disorders are discussed.

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References

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