Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2000 Dec;1(6):477-8.
doi: 10.1093/embo-reports/kvd124.

Proteolysis in Alzheimer's disease. Can plasmin tip the balance?

G Periz  1 , M E Fortini
Affiliations
Comment

Proteolysis in Alzheimer's disease. Can plasmin tip the balance?

G Periz et al. EMBO Rep. 2000 Dec.
No abstract available

PubMed Disclaimer

Figures

None
Fig. 1. Possible models for the role of plasmin in the development of Alzheimer’s disease. In unaffected individuals (left), plasmin influences the balance of α and β pathway activity by stimulating the α pathway (Ledesma et al., 2000) and degrading Aβ. Aβ, in turn, induces the plasmin system in a feedback mechanism (Wnendt et al., 1997; Van Nostrand and Porter, 1999; Tucker et al., 2000). In individuals with Alzheimer’s disease (right), reduced plasmin in neuronal rafts shifts the proteolytic balance towards the β pathway, leading to increased Aβ production and plaque formation (Model 1) (Ledesma et al., 2000). Alternatively, Aβ deposition may trigger inflammation, which induces inhibitors of the plasmin system, downregulating degradation and clearance of Aβ (Model 2) (Tucker et al., 2000).
None
None
See this image and copyright information in PMC

Comment on

References

    1. Fischer M.B., Roeckl, C., Parizek, P., Schwarz, H.P. and Aguzzi, A. (2000) Binding of disease-associated prion protein to plasminogen. Nature, in press. - PubMed
    1. Ikezu T., Trapp, B.D., Song, K.S., Schlegel, A., Lisanti, M.P. and Okamoto, T. (1998) Caveolae, plasma membrane microdomains for α-secretase-mediated processing of the amyloid precursor protein. J. Biol. Chem., 273, 10485–10495. - PubMed
    1. Kleiner D.E. Jr and Stetler-Stevenson, W.G. (1993) Structural biochemistry and activation of matrix metalloproteases. Curr. Opin. Cell Biol., 5, 891–897. - PubMed
    1. Ledesma M.D., Da Silva, J.S., Crassaerts, K., Delacourte, A., De Strooper, B. and Dotti, C.G. (2000) Brain plasmin influences APP α-cleavage and Aβ degradation and is reduced in Alzheimer’s disease brains. EMBO rep. 1, 530–535. - PMC - PubMed
    1. Lee S.-J., Liyanage, U., Bickel, P.E., Xia, W., Lansbury, P.T., Jr and Kosik, K.S. (1998) A detergent-insoluble membrane compartment contains Aβin vivo. Nature Med., 4, 730–734. - PubMed

Publication types

MeSH terms